|Title||Genomic Mapping by Anchoring Random Clones a Mathematical Analysis|
|Publication Type||Journal Article|
|Year of Publication||1991|
|Authors||Arratia GF, Lander ES, Tavare S, Waterman MS|
|Keywords||Biochemistry studies - Nucleic acids, Biophysics - Biocybernetics, Computational Biology Computational Biology Biochemistry and Molecular Biophysics Genetics Mathematical Biology Models and Simulations 03502, Genetics - General 04500, Mathematical biology and statistical methods 10062, purines and pyrimidines 10515|
A complete physical map of the DNA of an organism, consisting of an overlapping clones spanning the genome, is an extremely useful tool for genomic analysis. Various methods for the construction of such physical maps are available. One approach is to assemble the physical map by "fingerprinting" a large number of random clones and inferring overlap between clones with sufficiently similar fingerprints. E.S. Lander and M.S. Waterman (1988, Genomics 2:231-239) have recently provided a mathematical analysis of such physical mapping schemes, useful for planning such a project. Another approach is to assemble the physical map by "anchoring" a large number of random clones - that is, by taking random short regions called anchors and identifying the clones containing each anchor. Here, we provide a mathematical analysis of such a physical mapping scheme.