Publications

TitleGenomic Mapping by Anchoring Random Clones a Mathematical Analysis
Publication TypeJournal Article
Year of Publication1991
AuthorsArratia GF, Lander ES, Tavare S, Waterman MS
JournalGenomics
Volume11
Issue4
Pagination806-827
ISSN0888-7543
Accession NumberBacd199293040504
KeywordsBiochemistry studies - Nucleic acids, Biophysics - Biocybernetics, Computational Biology Computational Biology Biochemistry and Molecular Biophysics Genetics Mathematical Biology Models and Simulations 03502, Genetics - General 04500, Mathematical biology and statistical methods 10062, purines and pyrimidines 10515
Abstract

A complete physical map of the DNA of an organism, consisting of an overlapping clones spanning the genome, is an extremely useful tool for genomic analysis. Various methods for the construction of such physical maps are available. One approach is to assemble the physical map by "fingerprinting" a large number of random clones and inferring overlap between clones with sufficiently similar fingerprints. E.S. Lander and M.S. Waterman (1988, Genomics 2:231-239) have recently provided a mathematical analysis of such physical mapping schemes, useful for planning such a project. Another approach is to assemble the physical map by "anchoring" a large number of random clones - that is, by taking random short regions called anchors and identifying the clones containing each anchor. Here, we provide a mathematical analysis of such a physical mapping scheme.

URLhttp://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ResearchSoft&SrcApp=EndNote&DestLinkType=FullRecord&DestApp=BIOABS&KeyUT=BACD199293040504

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